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Results for search "Clinical Trials".

Health News Results - 198

Immune-Based Drug Fights Advanced Endometrial Cancer: Study

A drug used to treat several types of cancer is also an effective treatment for aggressive forms of endometrial cancer, the second most common cancer in women worldwide, a new clinical trial shows. The endometrium is the inner lining of the uterus.

"These findings suggest a long-term benefit to patients," said lead researcher Dr. David O'Malley, a gynecologic oncologist at the Ohio State ...

Drug Combo Boosts Outcomes for Advanced Melanoma

For people newly diagnosed with advanced melanoma, a combination of two immunotherapy drugs can double the amount of time their cancer remains progression-free, a clinical trial has found.

The treatment combines two drugs known as immune checkpoint inhibitors. One, called nivolumab (Opdivo), is already standard for advanced melanoma; the other, relatlimab, is not yet approved.

But b...

Drug Might Help Ease 'Sensory Demands' of Autism

A medication that acts on certain brain receptors can temporarily ease visual-processing problems in some adults with autism, a small study has found.

Researchers said it's far too early to know whether the drug, arbaclofen, could prove useful in managing those visual issues. But the findings do give in...

Once-a-Day HIV Pill Works Well for Kids

An international trial found that a once-a-day antiretroviral medication for kids with HIV is not only cheap and easy to take, but also better at suppressing HIV than standard treatments.

"Our findings provide strong evidence for the global rollout of dolutegravir for children with HIV," said Dr. Diana Gibb, a professor of epidemiology at University College London and a principal investig...

Could a High-Fiber Diet Help Boost Cancer Survival?

People undergoing immune-boosting therapy for advanced melanoma may respond better if they eat a high-fiber diet, a new study hints.

Researchers said much more study is needed, but their initial findings -- in both melanoma patients and lab mice -- suggest that

Fish Oil Has No Effect on Depression, Study Finds

They may have other proven health benefits, but new research shows that fish oil supplements don't prevent depression or improve mood.

Some experts recommend omega-3 fish oil supplements to help prevent depression in high-risk patients, but studies have yielded mixed results and there are no g...

Pfizer Vaccine Disappoints in Kids Ages 2 to 5

Two doses of a pediatric Pfizer-BioNTech COVID-19 vaccine failed to spur an adequate immune response in children aged 2 to 5, the companies announced Friday.

That's a setback for parents hoping to get their youngest children immunized against the new coronavirus as soon as possible.

The pediatric trials used a 3 microgram (mcg) dose of the vaccine — equivalent to about one-te...

Drug Combo May Fight a Tough Form of Breast Cancer

An experimental drug, added to chemotherapy, may benefit women with an aggressive form of breast cancer, suggests an early study offering much-needed good news.

The study involved women with "triple-negative" breast cancer, which accounts for about 15% to 20% of breast cancers among U.S. women. It is so called because the cancers lack receptors for the hormones estrogen and progesterone, ...

Could Gene Therapy Help Cure Sickle Cell Disease?

A gene therapy that could provide a permanent cure for sickle cell disease continues to show success through a third wave of patients, researchers report.

The therapy, LentiGlobin, restored normal blood function in 35 sickle cell patients who had the one-time procedure, according to clinical trial findings published Dec. 12 in the

  • Dennis Thompson HealthDay Reporter
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  • December 13, 2021
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  • New Treatment Greatly Boosts Survival for Kids With Aggressive Brain Cancer

    Children with the rare cancer neuroblastoma often succumb to the disease despite aggressive treatment. But researchers have found that adding an experimental antibody to that treatment, right off the bat, may improve their outlook.

    Of 64 children treated with the antibody in a clinical trial, 74% were still alive and free of a recurrence three years later. That compares with historical ra...

    New Asthma Drug Helps Kids, But Price Tag Is High

    Children with hard-to-control asthma may get relief from adding an injectable antibody drug to their standard treatment, a clinical trial has found.

    The drug, called dupilumab (Dupixent), has been available for several years to treat stubborn asthma in adults and teenagers. Based on the new findings, the

  • Amy Norton HealthDay Reporter
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  • December 9, 2021
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  • Clinical Trials Are Becoming More Diverse, But There's Still Work To Do

    U.S. cancer clinical trial participants have become more diverse in makeup, but certain groups remain underrepresented, a new study finds.

    It's important to have a wide range of participants in clinical trials, to find out if treatments are safe and effective for people with different characteristics, according to the National Cancer Institute (NCI), which has a number of initiatives to b...

    Drug Long Used for Alcoholism Might Fight Severe COVID-19

    A widely available drug used to treat alcoholism has potential as a COVID-19 treatment, researchers say.

    The investigators found that people taking disulfiram (Antabuse) for alcoholism had a lower risk of infection with SARS-CoV-2 and were less likely to die from COVID-19 if infected than those not taking the drug.

  • Robert Preidt
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  • November 23, 2021
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  • Wearable Vibration Device May Ease Parkinson's Tremor

    Physiotherapist David Putrino was working on a vibrating glove to help deaf people experience live music when a friend mentioned that the same technology might stop tremors in people with Parkinson's disease.

    Putrino, director of rehabilitation innovation for Mount Sinai Health System in New York City, was intrigued. The friend's father had Parkinson's, so they placed the new device on hi...

    Neurologists' Group Issues Guidance to Families on Controversial Alzheimer's Drug

    Neurologists must make sure Alzheimer's patients and their families understand that the controversial drug aducanumab does not restore mental function, the American Academy of Neurology (AAN) said in new position statement that includes ethical guidelines.

    "Aducanumab is not a cure for Alzheimer's disease, yet since it has been approved by the [U.S. Food and Drug Administration], patients...

    Trial Begins of Nasal Vaccine for Alzheimer's Disease

    The first human clinical trial of a nasal vaccine to slow the progression of Alzheimer's disease is set to begin after nearly 20 years of research.

    This is a "remarkable milestone," according to Dr. Howard Weiner, co-director of the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital in Boston.

    "Over the last two decades, we've amassed preclinical evidence sugg...

    Stem Cell Therapy Boosts Outcomes for Some Heart Failure Patients

    Heart failure patients who fit a specific profile can benefit from injection of stem cells delivered directly into their heart muscle, a new study finds.

    Patients with mild or moderate heart failure who have high levels of inflammation responded well to the stem cell injections, and experienced a decline in their risk of heart attacks, strokes and heart-related death, clinical trial resul...

    More Evidence That COVID Vaccines Are Safe for Cancer Patients

    COVID-19 vaccines are safe and effective for most cancer patients, a new study confirms.

    Cancer patients have an increased risk of severe illness and death from COVID because their immune systems have been weakened by their disease or treatments.

    "We pursued this study because there were limited data on the safety of SARS-CoV-2 vaccines in people with active cancer; no published pro...

    Placebo Effect Plays Big Role in Antidepressant's Impact on Anxiety: Study

    Illustrating the power of the mind to heal itself, new research suggests that the placebo effect could help drive antidepressants' effects against anxiety disorders.

    The placebo effect refers to an increase in the success of a treatment when a patient expects a benefit.

    In the new study, patients with s...

    We've Been Here Before: How Polio Vaccine Rollout Saved Millions of Young Lives

    An infection that can disable and kill stalks the land, but a brand-new vaccine offers hope that almost everyone, kids included, can evade it. After scientific testing, a nationwide rollout of the vaccine begins.

    Sound familiar?

    As the U.S. government gears up to offer COVID-19 shots to about 28 million 5- to 11-year-olds, high levels of vaccine hesitancy in some corners may make t...

    How Two People With HIV Suppressed Virus After Stopping Treatment

    There are two ways that HIV patients' bodies can keep the virus under control after they stop antiretroviral therapy, a new study shows.

    The findings could point to ways to help people with HIV keep the virus in remission without having to keep taking medications that can have long-term side effects, according to researchers at the U.S. National Institute of Allergy and Infectious Disease...

    Shorter Course of Post-Op Radiation May Work Well for Prostate Cancer Patients

    After prostate cancer surgery, men can safely undergo fewer radiation treatments at higher doses, a new clinical trial shows.

    Researchers found that the shorter regimen — given over five weeks, instead of seven — did not raise patients' odds of lasting side effects.

    Safety has been a "major concern" because when patients have fewer radiation treatments, the daily dose needs to b...

    Targeted High-Dose Radiation Helps Fight Advanced Lung Cancer

    High-dose radiation therapy may stall tumor growth in patients with advanced lung cancer who are not fully responding to drug therapies, a preliminary study suggests.

    The study involved patients whose lung cancer was considered "oligoprogressive." That means the cancer had spread to other sites in the body, and the patients were having a mixed response to standard systemic treatments — ...

    Moderna Says Its COVID Vaccine Works Well in Children Aged 6 to 11

    Moderna announced Monday that its COVID-19 vaccine safely triggers a strong immune response in children aged 6 to 11.

    Company data shows that a month after receiving both doses of the vaccine, children's antibody levels were 1.5 ...

    Pfizer Vaccine Booster Restores Nearly Full Protection, Company Says

    The Pfizer-BioNTech vaccine booster restored close to full protection against COVID-19 in a late-stage trial involving 10,000 people, the company announced Thursday.

    They said the booster was 95.6% effective and that they plan to submit the latest data to the U.S. Food and Drug Administration and regulators in other nations.

    "These results provide further evidence of the benefits of...

    Still Too Few Women in Stroke Treatment Clinical Trials

    Men still outnumber women in stroke therapy clinical trials, which means women may end up receiving less effective treatment, researchers say.

    For the new study, investigators analyzed 281 stroke trials that included at least 100 patients each and were conducted between 1990 and 2020.

    Of the nearly 590,000 total participants, 37.4% were women. However, the average rate of stroke amo...

    Another Study Suggests Too Much Fish Oil Could Trigger A-Fib

    A new study confirms that fish oil supplements may raise the risk of a common heart-rhythm disorder -- particularly when doses top 1 gram per day.

    At issue are medications and supplements containing omega-3 fatty acids, which are naturally found in fish oil.

    Fish is considered a generally heart-healthy food, but some studies have linked omega-3 in capsule form to an increased risk o...

    Anti-Nausea Drug May Boost Survival for Some Cancer Patients

    Patients who undergo surgery for certain types of cancer may have better short-term survival if they receive a particular anti-nausea drug, a preliminary study suggests.

    Among more than 74,000 patients who had cancer surgery, researchers found that those who received the drug -- called dexamethasone -- were less likely to die in the next 90 days.

    The vast majority of all patients su...

    New Hope for IBD Patients

    A drug previously approved for multiple sclerosis also can treat inflammatory bowel disease in some patients, a new clinical trial reports.

    The medication, ozanimod (Zeposia), proved effective in helping patients with ulcerative colitis, sending many into full remission, according to results being published Sept. 30 in the New England Journal of Medicine.

    Ulcerative colitis...

    Trials Show COVID Vaccines Well Worth It for Cancer Patients

    If you have cancer and you think coronavirus vaccines may do you little good, don't let your hesitation stop you from getting the shots: A pair of clinical trials finds that patients' immune systems ramped up after vaccination.

    The findings were presented this week during a virtual meeting of the European Society for Medical Oncology (ESMO Congress 2021).

    "We have to vaccinate all o...

    New Drug Combo Boosts Survival Against Aggressive Form of Breast Cancer

    New research offers good news for women with an aggressive HER2-positive breast cancer.

    A targeted therapy, trastuzumab deruxtecan (T-DXd), sold as Enhertu, triples the length of time that the cancer remains in check when compared with the current gold standard, trastuzumab emtansine (T-DM1).

    Both of these drugs are second-line treatment options for HER2-positive breast cancer that ...

    Trial Into Antioxidant for Parkinson's Disease Yields Disappointing Results

    FRIDAY, Sept. 17, 2021 (HealthDay News) -- Researchers hoped to show that the natural antioxidant urate could delay Parkinson's disease progression, but a study completed at Massachusetts General Hospital dashed those expectations.

    The trial enrolled nearly 300 individuals recently diagnosed with early Parkinson's disease, which affects the body's motor system. Symptoms such as tremors,...

    Ebola Vaccine Effective in African Clinical Trial

    An experimental Ebola vaccine appeared effective in children and adults in a clinical trial.

    Two doses of Johnson & Johnson's Ebola vaccine appear safe, well tolerated and produce a strong immune response in people over the age of 1, according to two just-published papers.

    ...

    Data Doesn't Support Need for COVID-19 Vaccine Boosters: Experts

    COVID-19 vaccine booster shots might not be needed for most people, according to a large international review.

    The review -- conducted by a team that included scientists from the World Health Organization and the U.S. Food and Drug Administration -- concluded that current vaccines are effective enough against severe COVID-19, even from the Delta variant, and that booster shots are unnece...

    Could a Long-Used Cholesterol Drug Fight Severe COVID-19?

    A drug that lowers cholesterol might help save hospitalized patients with COVID-19, a new, small Israeli study suggests.

    Researchers at Hebrew University of Jerusalem noted that COVID causes a big buildup of cholesterol, which results in inflammation in cells.

    In lab experiments, they found that the cholesterol-lowering drug fenofibrate (TriCor) effectively reduced damage to lung ce...

    Could Electrode 'Pulses' Cut Back, Leg Pain Without Drugs?

    A new approach to spinal cord stimulation may drastically reduce chronic back pain, a small pilot study suggests.

    The study, of 20 patients with stubborn low back pain, tested the effects of implanting electrodes near the spinal cord to stimulate it with "ultra-low" frequency electrical pulses.

    After two weeks, 90% of the patients were reporting at least an 80% reduction in their pa...

    Experimental Drug Could Cut Migraine Frequency

    A new pill specifically designed to prevent migraines appears to do the job, a new clinical trial finds.

    Atogepant cut patients' migraine days in half over 12 weeks of treatment, without causing serious side effects, the researchers said.

    Experts said the drug, if approved by the U.S. Food and Drug Administration, would give migraine sufferers a welcome new option.

    "There's a ...

    Far Too Few People of Color in U.S. Pancreatic Cancer Trials

    Racial and ethnic minorities in the United States are severely underrepresented in clinical trials testing cutting-edge treatments for pancreatic cancer, researchers say.

    "There are a ton of obstacles to get these patients into clinical trials," said senior author Dr. Jose Trevino, chairman of surgical oncology at Virginia Commonwealth University School of Medicine. "But this is how we're...

    New Drug Might Be Non-Surgical Option for Common Skin Cancers

    An experimental gel has shown early promise in treating the most common form of skin cancer -- hinting at a potential alternative to surgery in the future.

    Researchers tested the gel in 30 patients with basal cell carcinoma (BCC), a skin cancer diagnosed in more than 3 million Americans each year. The tumors rarely spread and are highly curable, usually through surgical removal.

    Eve...

    How Did the Pandemic Affect Cancer Clinical Trials?

    The pandemic widely disrupted medical care across the United States, but a new study reports that clinical trials testing cancer treatments were able to carry on.

    Researchers found that U.S. cancer trials quickly responded to the pandemic in the early months, allowing the studies to get back on track after an initial -- and steep -- drop-off in patient participation.

    That was partic...

    Drug Shows Promise in Easing Dementia-Linked Psychosis

    A drug that eases hallucinations in people with Parkinson's disease may be able to do the same for those with dementia, a new clinical trial finds.

    The medication, called Nuplazid (pimavanserin), is already approved in the United States for treating hallucinations and delusions related to Parkinson's.

    The new study, published July 22 in the New England Journal of Medicine, ...

    Chinese CoronaVac Vaccine 83.5% Effective Against Symptomatic COVID

    A double dose of China's CoronaVac vaccine is 83.5% effective against symptomatic COVID-19, researchers say.

    Their phase 3 trial included more than 10,000 people, aged 18 to 59, in Turkey who received either two doses of CoronaVac 14 days apart or an inactive placebo.

    An immune response analysis of 981 participants who got the vaccine found that it triggered a strong immune response...

    New Drug Shows Real Promise Against Celiac Disease

    An experimental drug can prevent intestinal damage caused by celiac disease, an early trial has found -- raising hopes that it could become the first medication for the serious digestive disorder.

    With celiac disease, the immune system attacks the lining of the small intestine when a genetically susceptible person eats gluten -- a protein found in wheat, rye and barley.

    The symptoms...

    'Laughing Gas' Shows Promise Against Tough-to-Treat Depression

    When antidepressants fail to rein in hard-to-treat depression, the common anesthetic most know as "laughing gas" might be a safe and effective alternative, new research suggests.

    The finding follows work with 28 patients struggling with "treatment-resistant major depression," a severe condition that investigators say affects about one-third of all patients - an estimated 17 million Americ...

    FDA Defends Approval of Controversial Alzheimer's Drug

    The U.S. Food and Drug Administration has approved the first new drug to treat Alzheimer's disease in nearly two decades, in a controversial decision that left the agency defending its reputation and its science.

    Aduhelm (aducanumab) treats Alzheimer's by clearing out amyloid beta, a sticky protein known to form plaques in the brains of early-stage patients.

    It is the first approved...

    'Historic' Decision Expected on U.S. Approval of Alzheimer's Drug

    The first drug ever shown to slow the progression of Alzheimer's disease could be approved by the U.S. Food and Drug Administration on Monday, but experts say that approval will be surrounded by controversy.

    In clinical trials, aducanumab showed a 22% reduction in the development of thinking and memory problems associated with Alzheimer's disease, according to a statement from the Alzheim...

    Antibiotics Won't Help Fight Lung-Scarring Disease IDF: Study

    Antibiotics do not reduce the risk of hospitalization or death in patients with a lethal lung disease known as idiopathic pulmonary fibrosis, a new study finds.

    "We were certainly disappointed in the results," said study co-author Dr. Imre Noth, chief of pulmonary and critical care medicine at UVA Health in Charlottesville, Va. "But we remain hopeful that in further downstream analyses, w...

    Newly Approved Drug Fights Lung Cancer Tied to Certain Genes

    A newly approved lung cancer drug shows promise in improving survival in patients whose tumors carry a common and tough-to-treat genetic mutation, researchers say.

    Sotorasib - brand name Lumakras - was approved May 28 by the U.S. Food and Drug Administration as a targeted therapy for non-small cell lung cancer patients with tumors that express the G12C mutation in the KRAS gene, ...

    Drug Lynparza Could Help Fight Some Early-Stage Breast Cancers

    A twice-daily pill can dramatically reduce the risk of breast cancer recurrence in women who are genetically prone to the disease, researchers report.

    The pill - olaparib (Lynparza) - works by blocking a natural enzyme called PARP that normally fixes DNA damage in healthy cells, but in these women actually promotes the growth of cancerous cells.

    Early high-risk breast cancer patient...

    NIH Starts Trial Assessing 'Mix & Match' COVID Vaccine Approach

    Moderna plus Pfizer? J&J plus Moderna? There's a new clinical trial underway to assess the safety and effectiveness of mixing different types of booster shots in adults who have been fully vaccinated against COVID-19.

    "Although the vaccines currently authorized by the U.S. Food and Drug Administration offer strong protection against COVID-19, we need to prepare for the possibility of ne...