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Results for search "Clinical Trials".

Health News Results - 156

'Laughing Gas' Shows Promise Against Tough-to-Treat Depression

When antidepressants fail to rein in hard-to-treat depression, the common anesthetic most know as "laughing gas" might be a safe and effective alternative, new research suggests.

The finding follows work with 28 patients struggling with "treatment-resistant major depression," a severe condition that investigators say affects about one-third of all patients - an estimated 17 million Americ...

FDA Defends Approval of Controversial Alzheimer's Drug

The U.S. Food and Drug Administration has approved the first new drug to treat Alzheimer's disease in nearly two decades, in a controversial decision that left the agency defending its reputation and its science.

Aduhelm (aducanumab) treats Alzheimer's by clearing out amyloid beta, a sticky protein known to form plaques in the brains of early-stage patients.

It is the first approved...

'Historic' Decision Expected on U.S. Approval of Alzheimer's Drug

The first drug ever shown to slow the progression of Alzheimer's disease could be approved by the U.S. Food and Drug Administration on Monday, but experts say that approval will be surrounded by controversy.

In clinical trials, aducanumab showed a 22% reduction in the development of thinking and memory problems associated with Alzheimer's disease, according to a statement from the Alzheim...

Antibiotics Won't Help Fight Lung-Scarring Disease IDF: Study

Antibiotics do not reduce the risk of hospitalization or death in patients with a lethal lung disease known as idiopathic pulmonary fibrosis, a new study finds.

"We were certainly disappointed in the results," said study co-author Dr. Imre Noth, chief of pulmonary and critical care medicine at UVA Health in Charlottesville, Va. "But we remain hopeful that in further downstream analyses, w...

Newly Approved Drug Fights Lung Cancer Tied to Certain Genes

A newly approved lung cancer drug shows promise in improving survival in patients whose tumors carry a common and tough-to-treat genetic mutation, researchers say.

Sotorasib - brand name Lumakras - was approved May 28 by the U.S. Food and Drug Administration as a targeted therapy for non-small cell lung cancer patients with tumors that express the G12C mutation in the KRAS gene, ...

Drug Lynparza Could Help Fight Some Early-Stage Breast Cancers

A twice-daily pill can dramatically reduce the risk of breast cancer recurrence in women who are genetically prone to the disease, researchers report.

The pill - olaparib (Lynparza) - works by blocking a natural enzyme called PARP that normally fixes DNA damage in healthy cells, but in these women actually promotes the growth of cancerous cells.

Early high-risk breast cancer patient...

NIH Starts Trial Assessing 'Mix & Match' COVID Vaccine Approach

Moderna plus Pfizer? J&J plus Moderna? There's a new clinical trial underway to assess the safety and effectiveness of mixing different types of booster shots in adults who have been fully vaccinated against COVID-19.

"Although the vaccines currently authorized by the U.S. Food and Drug Administration offer strong protection against COVID-19, we need to prepare for the possibility of ne...

Experimental Treatment Offers New Hope Against Lupus

An experimental antibody therapy may help ease skin symptoms from the autoimmune disease lupus, a small preliminary trial suggests.

Researchers found that a higher-dose version of the drug spurred a "clinically meaningful" symptom improvement for 87% of patients after one month.

But they also stressed that the findings are based on a small "phase 1" trial - a type of study designed ...

Moderna COVID-19 Vaccine Highly Effective in Kids 12 and Older

Moderna's coronavirus vaccine fully protects children aged 12 to 17, the company announced Tuesday.

In a clinical trial that included more than 3,700 young volunteers, there were no cases of symptomatic COVID-19 infection in the two-thirds of participants who received both doses of the vaccine, which translates into an efficacy rate of 100%.

That's the same rate that was reported re...

New Drug Shows Promise Against Tough-to-Manage Asthma

An experimental injectable drug appears more versatile than existing medications in treating people with different forms of severe, hard-to-control asthma, clinical trial results show.

There are many different types of asthma brought on by many different triggers, and a number of monoclonal antibody medications -- called "biologics" -- have been crafted to target distinct asthma triggers....

Gene Therapy Uses HIV to Rescue Kids Born Without Immune System

Cora Oakley is a rough-and-tumble 4-year-old who loves gymnastics and outdoor activities, particularly if it involves bouncing on a trampoline.

It's hard to tell from looking at her that she was born without an immune system. Kids with this condition can acquire dangerous, life-threatening infections from day-to-day activities as simple as going to school or playing with friends.

"I...

Drug Saxenda Aids Weight Loss -- But You Should Exercise, Too

The weight-loss drug Saxenda can keep extra pounds off -- but combining it with exercise brings a bigger payoff, a new clinical trial finds.

The study found that some longstanding advice is valid: Prescription weight-loss drugs work best when used along with -- and not in place of -- lifestyle changes.

Saxenda (liraglutide) is a prescription drug approved in the United States for sp...

Who's Most Likely to Join a Clinical Trial?

Cancer patients most likely to sign up for clinical trials during their treatment include people of color, those with higher incomes and those who are younger, a new study finds.

"This study informs our understanding of who is participating in cancer clinical trials," said study author Dr. Lincoln Sheets, an assistant research professor at the University of Missouri School of Medicine, in...

Researchers Seek Antiviral Pill That Would Ease COVID Severity

While COVID-19 research efforts must now shift toward the development of a pill that can prevent serious illness in the recently infected, experts say.

"We need a pill that can keep people out of the hospital, and the time to develop that is right now," Dr. Rajesh Gandhi said during a Thursday media briefing by the Infectious Diseases Society of America. He is director of HIV Clinical Ser...

Race Against Time: Stricken With ALS, She's Seeking Access to Experimental Drug

Like many proud moms, Lisa Stockman-Mauriello of Summit, N.J., is looking forward to exciting milestones in lives of her three sons over the coming months: One will graduate college, one will enter college, and the third will begin high school.

But unlike other moms, it's not guaranteed that she'll be there to experience them.

Lisa, 51, has amyotrophic lateral sclerosis (ALS), a di...

New Drug May Be Better Psoriasis Treatment

A breakthrough psoriasis drug is better at treating the itchy and painful skin disease than medicines already on the market, according to results from two clinical trials.

There was a "night and day difference" in the results from bimekizumab compared against two established psoriasis drugs, secukinumab (Cosentyx) and adalimumab (Humira), said Dr. Mark Lebwohl, a co-researcher in one of t...

'Nerve Zap' Pain Treatment Could Cut Need for Opioids After Surgeries

An emerging technology could zap your post-op pain away -- little or no opioids needed.

The technique is called percutaneous peripheral nerve stimulation. It involves inserting a small wire next to a nerve and using a stimulator to deliver a mild electrical current to the affected area, interrupting pain transmission.

A team led by Dr. Brian Ilfeld, of the University of California, ...

New Hope Against a Rare but Incurable Eye Cancer

A cutting-edge experimental drug cuts nearly in half the risk of death among patients with a rare but aggressive cancer of the eye, new clinical trial data show.

Tebentafusp has now become the first drug shown to improve overall survival in patients with uveal melanoma, said Dr. Antoni Ribas, immediate past president of the American Association of Cancer Research (AACR), in a

  • Dennis Thompson HealthDay Reporter
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  • April 20, 2021
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  • Full Page
  • 'Magic Mushroom' Hallucinogen as Good as Antidepressants: Study

    The magic ingredient in "magic mushrooms" may be at least as effective as standard medication for depression, an early clinical trial suggests.

    The study of 59 patients with major depression tested the antidepressant escitalopram (Lexapro) against psilocybin, which is the psychedelic substance in hallucinogenic mushrooms.

    Over six weeks, it appeared that just two doses of psilocybi...

    Diabetes Can Lead to Amputations, But Stem Cell Treatment Offers Hope

    One of the most dangerous complications of diabetes is a foot ulcer that won't heal, but now a preliminary study finds that a type of stem cell found in body fat may be a powerful remedy for these severe foot wounds.

    The study included 63 patients with non-healing diabetic foot ulcers who were given injections of cells from their own body fat. Over the next year, the treatment healed the ...

    Therapeutic Cancer Vaccine Shows Promise Against Multiple Tumor Types

    Marc Baum went through all the usual steps to treat his bladder cancer -- a couple of surgeries, radiation therapy and chemotherapy, all in a three-month period.

    But doctors hope that an extra step -- an experimental vaccine -- will be what keeps Baum's cancer from coming back.

    A vaccine that uses genetics to teach a person's immune system how to precisely target the cancer has prov...

    Pandemic Has Put Many Clinical Trials on Hold

    Fewer clinical trials are being completed during the pandemic, which experts say could affect medical research for decades to come.

    Previously, it was reported that more than 80% of clinical trials were suspended between March 1 and April 26, 2020, with the pandemic cited as the main reason.

    In this study, researchers at Penn State College of Medicine examined more than 117,000 tria...

    NIH Starts Trial Looking at Rare Allergic Reactions to COVID Vaccines

    A new clinical trial will investigate whether people who are highly allergic or have what's known as a mast cell disorder are at higher risk for a sudden allergic reaction to the Moderna or Pfizer COVID-19 vaccines.

    "The public understandably has been concerned about reports of rare, severe allergic reactions to the Moderna and Pfizer-BioNTech COVID-19 vaccines," said Dr. Anthony Fauci, d...

    No Proof COVID Vaccines Can Trigger Guillain-Barré Syndrome

    Two people in the Johnson & Johnson COVID-19 vaccine trial developed Guillain-Barré syndrome, but it's highly doubtful the vaccine is to blame, according to a just-published case study.

    Although both people were in the same trial, one was given the vaccine and the other was given a placebo of saline solution.

    "That strengthens the possibility that the case in our report may have be...

    Can Vaccinations Stop COVID Transmission? College Study Aims to Find Out

    It's the question everyone wants answered because reopening the world depends on it: Can coronavirus vaccines stop transmission of the virus?

    Now, 21 universities across the United States are teaming up to find out.

    The project, called Prevent COVID U, was started by the COVID-19 Prevention Network housed at the Fred Hutchinson Cancer Research Center in Seattle.

    The study inc...

    Can a Drug Help Prevent Diabetic Vision Loss?

    The overall eye health of people with diabetes benefits from preventive drug injections directly into the eyeball, but it's too soon to tell whether such treatment will better preserve their vision long-term, new clinical trial results show.

    Regular injections of aflibercept (Eylea) caused a more than threefold reduction in blood vessel leakage inside the retina, and a more than twofold r...

    Will High-Protein Diets Help the Middle-Aged Build Muscle?

    Middle-aged adults looking to boost their muscle mass do not need to bulk up on protein, a new study suggests.

    Researchers found that 10 weeks of strength training plus a moderate amount of protein were enough to build muscle in previously sedentary middle-aged people. And extra protein brought no added gains.

    The findings run counter to a common belief among exercisers, said resear...

    Coming Soon: Once-a-Week Insulin Injections?

    Daily insulin jabs can be the bane of existence for people who live with type 2 diabetes, but an investigational once-weekly insulin shot may be a game changer for these folks.

    While the research is still in its early stages, the new drug called basal insulin Fc (BIF) is given once a week and appears to be just as effective at controlling blood sugar (glucose) as insulin degludec, the gol...

    Common Type 2 Diabetes Meds Won't Raise Breast Cancer Risk: Study

    Widely used diabetes and obesity drugs don't increase the risk of breast cancer, a new study indicates.

    The drugs -- called glucagon like peptide-1 receptor agonists or GLP-1 RAs for short -- are effective in treating type 2 diabetes and obesity and in reducing heart disease. But some previous studies have suggested a possible link between them and breast cancer.

    GLP-1RAs include al...

    Disappointment and Hope From Two HIV Prevention Trials

    An antibody infusion being tested for preventing HIV does not seem to thwart most infections -- but its success against certain strains of the virus suggests researchers are on the right track.

    That's the takeaway from a clinical trial that put the antibody, called VRC01, to the test in 2,700 people at high risk of contracting HIV.

    Researchers found that infusions of the antibody ev...

    Could a New Drug Help Ease Alzheimer's?

    About 7 out of 10 Alzheimer's patients wound up free of the brain plaques that are a hallmark of the disease after treatment with a potentially breakthrough experimental drug, clinical trial results show.

    The drug, donanemab, also significantly slowed the patients' brain decline, according to findings published March 13 in the New England Journal of Medicine.

    Donanemab diss...

    Medical Bill Worries Tied to Worse Outcomes for Cancer Patients: Study

    Financial worries can hamper the success of cancer treatment and raise patients' risk of death, according to a new study that offers the first evidence of such a link.

    "The association we found was very strong, and very concerning," said senior study author Dr. Anurag Singh, director of radiation research at Roswell Park Comprehensive Cancer Center in Buffalo, N.Y. "If you are worried abo...

    Could a Drug Prevent Type 1 Diabetes in Those at Risk?

    Just two weeks of treatment with an experimental drug can delay the onset of type 1 diabetes by several years, researchers report.

    The drug, called teplizumab, is already under review by the U.S. Food and Drug Administration based on earlier evidence of its effectiveness.

    If it gets the green light, it would become the first drug approved for delaying type 1 diabetes in high-risk pe...

    'Rerouting' Brain Blood Flow: Old Technique Could Be New Advance Against Strokes

    Doctors are testing a decades-old surgical technique as a new way to treat certain stroke patients. And the preliminary results look promising, they say.

    At issue are strokes caused by intracranial atherosclerosis, where blood vessels within the brain become hardened and narrowed.

    Strokes occur when the blood supply to the brain is disrupted, depriving tissue of oxygen and nutrients...

    NIH Halts Trial of Convalescent Plasma for Mild COVID-19

    A clinical trial evaluating the use of convalescent plasma in patients with mild to moderate COVID-19 symptoms has been halted because the treatment didn't benefit them, according to the U.S. National Institutes of Health.

    Convalescent plasma (also called "survivor's plasma") is derived from the blood of patients who have already recovered from COVID-19. It's thought that infusions of the...

    Does an Arthritis Drug Help Patients Battling Severe COVID? It Depends on the Study

    Two new studies suggest that the jury is still out on whether the arthritis drug tocilizumab helps those with severe COVID-19.

    Both reports were published recently in the New England Journal of Medicine. The first, from scientists at the University of California, San Diego, found tocilizumab didn't improve outcomes or reduce the risk of death in patients with severe COVID-19 pneu...

    Stem Cell Injections Show Early Promise Against Spinal Cord Injuries

    Spinal cord injuries can be devastating to the more than 17,000 Americans who suffer them each year. But many patients may have new reason for hope: Early research suggests infusions of stem cells could help them regain lost sensation and movement.

    These improvements may occur within days or weeks of receiving the stem cell therapy, and can last at least six months, according to the small...

    Rheumatoid Arthritis Meds May Help Fight Severe COVID-19

    Rheumatoid arthritis drugs may save lives of patients hospitalized with severe cases of COVID-19, according to a groundbreaking clinical trial.

    The findings, first announced in January, have now been peer-reviewed and published in a major medical journal.

    "We are delighted that our full results are now published after peer review. This confirms the robustness of our findings, that t...

    New Hope for Better Treatments Against Macular Degeneration

    A number of new treatments for age-related macular degeneration (AMD), a progressive eye disease, are under development. AMD is a leading cause of vision loss in older people.

    About 11 million Americans have AMD, which affects part of the eye that allows you to see fine detail. There are two types: wet and dry. Wet AMD is treated with eye injections every month or two, and dry AMD with an...

    New Rabies Prevention Treatment Also Works in Kids: Study

    Getting bitten by a dog or wild animal is frightening, especially for kids, but a new study may help relieve some of the worry about catching rabies.

    The rabies prevention treatment KEDRAB is safe and effective for patients 17 and younger, a groundbreaking pediatric clinical trial has shown.

    The trial included 30 kids with suspected or confirmed rabies exposure who were treated with...

    Injected Drug Delivers Up to 20% Weight Loss in Trial

    A new weight-loss drug is almost twice as effective as current medications, clinical trial results show, and experts say it could revolutionize the treatment of obesity.

    Overweight and obese people lost an average 15% of their body weight using a weekly injectable 2.4 milligram dose of semaglutide (Ozempic), a new report reveals.

    What's more, one-third of all participants lost 20% o...

    Interferon Shot Might Keep COVID-19 Patients Out of the Hospital

    An experimental antiviral drug known as peginterferon lambda can speed up COVID-19 patients' ability to shed the virus and recover, scientists report.

    "One of the important things about this treatment that's different from the other things that have been studied for COVID-19 is that this is working on the person, not on the virus. So it doesn't depend at all on the strain or the sequence ...

    CBD Won't Help Addicts Kick the Coke Habit: Study

    Cannabidiol (CBD) products are seemingly everywhere these days, but they won't help cure a cocaine addiction, a Canadian study finds.

    CBD, a chemical in the cannabis plant, has long been touted as a treatment for cocaine addiction. But researchers at the University of Montreal Hospital Research Center found that it doesn't lessen addicts' craving for cocaine or reduce their risk of relaps...

    Strict Low-Carb Diets Could Push Type 2 Diabetes Into Remission, But Effect Fades

    Tough limits on carbohydrates in your meals can help get type 2 diabetes under control -- but the benefits typically wane over time, a new research review shows.

    The analysis of 23 small trials found that low-carb diets worked better than other eating plans in helping people lose weight and send their type 2 diabetes into remission. That was true, at least, in the first six months.

    ...

    New Hope Against Diseases Marked by Progressive Scarring of Lung Tissue

    An inhaled medication might make every day physical activity a bit easier for patients with serious scarring of the lungs, a new clinical trial finds.

    The study, published online Jan. 13 in the New England Journal of Medicine, involved patients with high blood pressure in the lungs caused by interstitial lung disease (ILD).

    ILD is a broad term for progressive scarring of th...

    Johnson & Johnson's One-Dose COVID Vaccine Promising in Early Trial

    WEDNESDAY, Jan. 13, 2021 -- A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts.

    The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan. 13 in the New England Journal...

    Vaccine Rollout Could Have Americans Back to Normalcy by Summer, Expert Says

    A return to normal life in America might happen sooner than many expect, one of the nation's leading vaccine experts told HD Live! this week.

    As the new coronavirus rages across the country, President-elect Joe Biden has set a goal of one million doses of vaccine delivered every day once he takes office. If that ambitious target is realized, everyday conditions in the United States might ...

    Could Umbilical Cord Stem Cells Be a Lifesaver Against Severe COVID-19?

    Stem cells derived from a baby's umbilical cord can help save the lives of the sickest COVID-19 patients, results from a small new clinical trial suggest.

    Severely ill COVID patients who received two intravenous doses of stem cells three days apart were much more likely to survive and recover quickly, researchers found.

    "The results are quite spectacular," said senior researcher Dr....

    Study Finds No Benefit From Supplemental Oxygen During Labor

    For decades, women have commonly been given oxygen during childbirth, but a new research review finds little evidence it benefits newborns.

    The American College of Obstetricians and Gynecologists recommends that women be given supplemental oxygen when fetal heart monitoring shows an abnormal heart rate. That's based on the possibility that oxygen deprivation is causing the problem.

    ...

    Trials Find Full-Dose Blood Thinners May Harm, Not Help, COVID Patients in ICU

    Because COVID-19 is known to raise the odds for dangerous blood clots, blood thinners have quickly become part of routine care for many hospitalized patients.

    But three clinical trials testing full doses of these drugs in COVID-19 patients have now paused recruitment of critically ill patients because the medications could end up doing more harm than good.

    According to experts at th...